Sulfasalazine
Conditions Treated
Sulfasalazine is used to treat bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain in patients with ulcerative colitis, a condition in which the bowel is inflamed. Sulfasalazine delayed-release (Azulfidine EN-tabs) is also used to treat rheumatoid arthritis in adults and children whose disease has not responded well to other medications. Sulfasalazine is in a class of medications called anti-inflammatory drugs. It works by reducing inflammation (swelling) inside the body.
Possible Side Effects
What Side Effects Can This Cause?
Sulfasalazine may cause side effects. Sulfasalazine causes temporary infertility in males. Fertility returns when the medicine is stopped. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless.Tell your doctor if any of these symptoms are severe or do not go away:
- diarrhea
- headache
- loss of appetite
- upset stomach
- vomiting
- stomach pain
If you have any of the following symptoms, stop taking sulfasalazine and call your doctor immediately:
- skin rash
- itching
- hives
- swelling
- sore throat
- fever
- joint or muscle aches
- pale or yellow skin
- difficulty swallowing
- tiredness
- unusual bleeding or bruising
- weakness
Usage Instructions
How Should This Medication Be Used
Sulfasalazine comes as regular and delayed-release (enteric-coated) tablets. It usually is taken four times a day in evenly spaced doses throughout the day so that no more than 8 hours separates any two doses, if possible. Take sulfasalazine after a meal or with a light snack, then drink a full glass of water. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sulfasalazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Swallow tablets whole; do not crush or chew them. Drink plenty of fluids (at least six to eight glasses of water or other beverage per day) while taking sulfasalazine. Continue to take sulfasalazine even if you feel well. Do not stop taking sulfasalazine without talking to your doctor.
Are There Any Special Instructions
Before taking sulfasalazine, tell your doctor if you are allergic to sulfasalazine, sulfapyridine, aspirin, choline magnesium trisalicylate (Triosal, Trilisate), choline salicylate (Arthropan), mesalamine (Asacol, Pentasa, Rowasa), salsalate (Argesic-SA, Disalcid, Salgesic, others), sulfa drugs, trisalicylate (Tricosal, Trilisate),or any other drugs. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially digoxin (Lanoxin), folic acid, and vitamins. tell your doctor if you have or have ever had asthma, kidney or liver disease, porphyria, blood problems, or blockage in your intestine or urinary tract. plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Sulfasalazine may make your skin sensitive to sunlight.
Brand Names
Common Brand Names for This Medication
- Azulfidine®
- Azulfidine® EN-tabs®
Overdose
What To Do In The Case of Emergency
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Forgotten Doses
What Should I Do If I Forget A Dose?
Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Additional Information
What Are the Storage Conditions for this Medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
What Other Information Should I Know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to sulfasalazine. Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.