Ergotamine And Caffeine

Conditions Treated

The combination of ergotamine and caffeine is used to prevent and treat migraine headaches. Ergotamine is in a class of medications called ergot alkaloids. It works together with caffeine by preventing blood vessels in the head from expanding and causing headaches.

Possible Side Effects

What Side Effects Can This Cause?

Ergotamine and caffeine may cause side effects. Tell your doctor if either of these symptoms is severe or does not go away:

nausea
vomiting

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

leg weakness
chest pain
rapid heartbeat
slow heartbeat
dizziness
muscle pain in the legs or arms
blue hands and feet
swelling
itching
pain, burning, or tingling in the fingers and toes

Ergotamine and caffeine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].

Usage Instructions

How Should This Medication Be Used

The combination of ergotamine and caffeine comes as a tablet to take by mouth and as a suppository to insert rectally. It is usually taken at the first sign of a migraine headache. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ergotamine and caffeine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. To use the tablets, follow these steps:

Take two tablets at the first sign of a migraine.

Lie down and relax in a quiet, dark room for at least 2 hours.

If the headache pain does not stop within 30 minutes, take one or two more tablets.

Take one or two tablets every 30 minutes until the headache pain stops or you have taken six tablets.

If the headache pain continues after you have taken six tablets, call your doctor. Do not take more than six tablets for one headache unless your doctor specifically tells you to do so.

Do not take more than six tablets in 24 hours or 10 tablets in 1 week. If you need more, call your doctor.

To use the suppositories, follow these steps:

If the suppository feels soft, place it in ice cold water (before removing foil wrapper) until it hardens.

Remove the wrapper and dip the tip of the suppository in water.

Lie down on your left side and raise your right knee to your chest. (A left-handed person should lie on the right side and raise the left knee.)

Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in children and 1 inch (2.5 centimeters) in adults. Hold it in place for a few moments.

Wash your hands thoroughly; then lie down and relax in a dark, quiet room for at least 2 hours.

If the headache pain does not stop within 1 hour, insert another suppository.

If the headache pain continues after you have inserted two suppositories, call your doctor. Do not use more than two suppositories for one headache unless your doctor specifically tells you to do so.

Do not use more than five suppositories in 1 week. If you need more, call your doctor.

What Dietary Instructions Should I Follow

Talk to your doctor about drinking grapefruit juice while taking this medicine.

Are There Any Special Instructions

Before taking ergotamine and caffeine, tell your doctor and pharmacist if you are allergic to ergotamine, caffeine, or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: clotrimazole, fluconazole (Diflucan), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), medications for asthma and colds, metronidazole (Flagyl), nefazodone (Serzone), propranolol (Inderal), saquinavir (Invirase, Fortovase), and zileuton (Zyflo). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have or have ever had high blood pressure; problems with circulation; coronary artery disease; a severe blood infection; or kidney or liver disease.

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Brand Names

Common Brand Names for This Medication

Cafatine® Rectal Suppository (as a combination product containing Caffeine, Ergotamine)
Cafergot® (as a combination product containing Caffeine, Ergotamine)
Cafergot® Rectal Suppository (as a combination product containing Caffeine, Ergotamine)
Cafetrate® Rectal Suppository (as a combination product containing Caffeine, Ergotamine)
Ercaf® (as a combination product containing Caffeine, Ergotamine)
Migergot® Rectal Suppository (as a combination product containing Caffeine, Ergotamine)
Wigraine® (as a combination product containing Caffeine, Ergotamine)

Overdose

What To Do In The Case of Emergency

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include:

vomiting
numbness
tingling sensation
pain
blue hands and feet
lack of pulse
dizziness or lightheadedness
fainting
drowsiness
unconsciousness
coma
seizures

Additional Information

What Are the Storage Conditions for this Medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from light and excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What Other Information Should I Know?

Keep all appointments with your doctor. If you take large doses of this medication for a long time, you may have a severe headache for a few days after stopping the medication. If the headache lasts for more than a few days, call your doctor. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

ASHS Disclaimer

Click here for the American Society of Health-System Pharmacists, Inc. Disclaimer. AHFS® Consumer Medication Information. © Copyright, 2011. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commerical use must be authorized by ASHP.