Signs of Steven Johnson syndrome

Steven Johnson Syndrome

Description

A serious inflammation of the skin and mucous membranes that requires aggressive treatment and hospitalization. The skin becomes red, and blisters and sloughs after dying. Steven-Johnson is an extension of erythema multiforme. The disorder is felt to be an allergic reaction to certain medications or infections. The most common medications involved are sulfa drugs, tetracycline, amoxicillin, ampicillin, anti-seizure medications, nonsteroidal anti-inflammatory drugs/NSAIDs (ibuprofen, naproxen) and allopurinol.

Symptoms

Multiple skin lesions, lesions and ulcerations in the mouth, swelling and redness of the eyes, lesions in the vagina, itching, fever, general ill feeling, joint aches.

Tests

A history and physical exam will be performed. Tests to identify dehydration and other damage done may be performed. Rarely a skin biopsy is performed.

Standard Workup

CBC
Chem 12

Treatment

Treatment includes: hospitalization, intensive burn care treatment, and intravenous fluids. Patients can become dangerously dehydrated and acquire infections of their skin lesions.