Serotonin Syndrome (Severe Med Reaction)
Description
A disorder characterized by dangerously high levels of serotonin, a neurotransmitter produced in the brain. High levels of serotonin occur when medications or a combination of medications are taken. These medications include: antidepressants, triptans for migraines, pain medications, anti-nausea medications, lithium, over-the-counter cold medications, and some illicit drugs (such as cocaine). Patients can experience restlessness, rapid heartbeat, fever, muscle rigidity, altered mental status and seizures.
Symptoms
Restlessness, hallucinations, incoordination, fast heart beat, rapid changes in blood pressure, fever, overactive reflexes, nausea, vomiting, diarrhea, seizures, coma.
Tests
A history and physical exam will be performed. Tests to rule out other causes of the symptoms may be done.
- CBC
- Chem 12
- EKG
- CT Scan
- UA
- BHCG
- X-Ray
Treatment
Therapy includes supporting the vital signs, protecting the patient from harming themselves, and withdrawing the medications that caused the syndrome. Medications may include: cyproheptadine (Periactin), benzodiazepines (Valium, Ativan), and/or blood pressure medications. Consider calling the National Poison Control Phone Number for further information or assistance: 1-800-222-1222.
Research
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