Panhypopituitarism (Hypopituitarism)
Description
A rare disorder that results from decreased production of the hormones of the pituitary gland.The pituitary gland is located behind the nose and between the ears. The gland produces hormones that control almost every major function of the body. These hormones include growth hormone, thyroid stimulating hormone, follicle stimulating hormone, leutenizing hormone, prolactin ACTH, antidiuretic hormone and oxytocin. The main causes of panhypopituitarism is damage to the pituitary gland from trauma, cancer, infection, stroke, and blood loss during pregnancy.
Symptoms
Since the hormones are important to every major function of the body the symptoms are widespread and non-specific. Symptoms include: fatigue, headaches, nausea, constipation, weight loss, decreased appetite, abdominal pain, cold intolerance, heat intolerance, visual problems, pubic hair loss, joint pain, hoarseness, facial swelling, increased thirst, increased urination, near fainting.
Tests
A history and physical exam will be performed. Blood tests will be done to measure the missing or low level of hormones. Imaging testing may be done to determine the cause of the pituitary damage.
- TSH
- FSH
- LH
- Chem 12
- CBC
- CT Scan
- MRI
- X-Ray
Treatment
Therapy consists of replacing the missing hormones. The medications used include: corticosteroids, thyroid hormone, sex hormones, growth hormone, DDAVP (desmopressin).
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