Signs of Miller Fisher Syndrome

Description

A rare disorder that causes weakness of the eye muscles followed by weakness and incoordination of the arms and legs. It is felt to be a variant of Guillain-Barre’ syndrome, and similar to this disorder tends to occur after a viral infection. This disorder can be very serious and lead to weakness of the breathing muscles and death. This disease is felt to be caused by an abnormal production of antibodies. Most patients with this disorder will recover with treatment but total recovery can take as long as 6 months.

Symptoms

Symptoms tend to occur 2-4 weeks after a viral illness and consist of drooping eye lids, double vision, incoordination of the arms and legs (ataxia), breathing problems, arm weakness, and leg weakness.

Tests

A history and physical exam will be performed. Nerve conduction studies may be done. A spinal tap (lumbar puncture) is usually performed to evaluate the cerebrospinal fluid. A CT scan and/or MRI of the brain can be helpful in ruling out other causes of the symptoms.

Standard Workup

CT Scan
MRI

Treatment

Therapy depends on the extent of the disease and the severity of the symptoms. Treatment may consist of intravenous immunoglobulin or plasmapheresis. The patient's breathing will be watched closely and some patients may require a breathing tube and mechanical ventilation.